Linker A: S-HyNic Crosslinker- Most Popular!

S-HyNic is used to activate amine containing biomolecules for conjugation to 4FB containing biomolecules or surfaces. The HyNic on activated biomolecules is not stable long term and should be reacted right away with the 4FB biomolecule of choice.

S-HyNic Crosslinker (SANH)	5 x 1.0 mg	S-1002-105	$150
S-HyNic Crosslinker (SANH)	10 mg	S-1002-010	$225

Linker B: S-4FB Crosslinker- Most Popular!

S-4FB is used activate amine containing biomolecules for conjugation to HyNic containing biomolecules or surfaces. The 4FB is stable long-term and may be used to pre-activate large quantities of oligos, enzymes, carrier proteins or surfaces that are stored for multiple conjugation projects over time.

S-4FB Crosslinker	25 mg	S-1004-025	$150
S-4FB Crosslinker	5 x 1.0mg	S-1004-105	$100

S-HyNic Conjugation Kit

This conjugation kit is a general kit that can be used to conjugate any amine containing biomolecules to any other amine containing biomolecule. The kit includes our two most popular linkers, S-HyNic and S-4FB, plus all of the necessary reagents and buffers to quantitatively activate and conjugate your biomolecules.

S-HyNic Conjugation Kit

Kit mg

S-9002-1

$495

C6-S-HyNic Crosslinker

C6-S-HyNic has a 6 carbon chain for extended linker length. It is used to HyNic activate amine containing biomolecules for conjugation to 4FB containing biomolecules or surfaces. The HyNic on activated biomolecules is not stable long-term and should be reacted right away with the 4FB biomolecule of choice.

C6-S-HyNic Crosslinker	5 x 1.0 mg	S-1010-105	$175
C6-S-HyNic Crosslinker	10 mg	S-1010-010	$250

Sulfo-S-HyNic Crosslinker

Sulfo-S-HyNic is the water soluble version of the standard S-HyNic linker. It is used to HyNic activate amine containing biomolecules for conjugation to 4FB containing biomolecules or surfaces. The Sulfo version of the S-HyNic is typically used for proteins and surfaces sensitive to organic solvents.

Sulfo S-HyNic Crosslinker	5 x 1.0 mg	S-1011-105	$225
Sulfo S-HyNic Crosslinker	10 mg	S-1011-010	$295

SHTH Crosslinker

SHTH is used to activate amine containing biomolecules for conjugation to 4FB containing biomolecules or surface. The SHTH forms a non-aromatic bond with S-4FB and therefore forms a less stable hydrazone bond than does the S-HyNic with 4FB. SHTH is most often used to activate oligos for conjugation to 4FB-activated biomolecules to prevent dimerization of the oligo. An additional feature of SHTH is that it is more stable on the activated biomolecule than the HyNic for long-term storage before conjugation with its 4FB compliment.

SHTH

10 mg

S-1003-010

$225

MHPH Crosslinker

MHPH has a maleimide reactive group used to HyNic activate thiol containing biomolecules for conjugation to 4FB containing biomolecules or surfaces. The HyNic on activated biomolecules is not stable long-term and should be reacted right away with the 4FB biomolecule of choice.

MHPH Crosslinker

10 mg

S-1009-010

$250

HyNic Silane Crosslinker

HyNic Silane may be used to stably add a HyNic linker to glass/silica surfaces.

HyNic Silane

25 mg

HL-1002-025

$350

C6-S-4FB Crosslinker

C6-S-4FB has a 6 carbon chain for extended linker length. C6-S-4FB is similar to S-4FB in its reactivity and long-term stability. The hydrophobic 6-chain carbon linker does make proteins more sensitive to precipitation and should not be used to modify proteins with known solubility issues.

C6-S-4FB Crosslinker	5 x 1.0 mg	S-1007-105	$150
C6-S-4FB Crosslinker	25 mg	S-1007-025	$250

PEG4/PFB Crosslinker

PEG4/PFB is the PEG version of S-4FB. It utilizes a pentafluor instead of the standard NHS-ester for activation. The PEG4 linker is useful for extending the linker length and maintaining solubility. PEG4/PFB is similar to S-4FB in its reactivity and long-term stability.

PEG4/PFB Crosslinker

10 mg

S-1034-010

$200

Sulfo-S-4FB Crosslinker

Sulfo-S-4FB is the water soluble version of the standard S-4FB linker. It is used to activate amine containing biomolecules for conjugation to HyNic containing biomolecules or surfaces. The Sulfo version of the S-4FB is typically used for proteins and surfaces sensitive to organic solvents.

Sulfo-S-4FB Crosslinker	5 x 1.0 mg	S-1008-105	$150
Sulfo-S-4FB Crosslinker	25 mg	S-1008-025	$200

MTFB Crosslinker

MTFB has a maleimide reactive group used to 4FB activate thiol containing biomolecules for conjugation to HyNic containing biomolecules or surfaces.

MTFB Crosslinker

5 x 1.0 mg

S-1035-105

$150

SS-S-4FB Crosslinker

SS-S-4FB is the disulfide cleavable version of the standard S-4FB. This linker should only be used for applications in which cleaving is necessary.

SS-S-4FB Cleavable Crosslinker	5 x 1.0 mg	S-1037-105	$150
SS-S-4FB Cleavable Crosslinker	25 mg	S-1037-025	$200

4FB Amidite

4FB amidite is used for solid phase synthesis of 4FB onto the 5’end of oligos.

4FB Amidite

250 mg

S-1005-250

$325

4FB Silane Crosslinker

4FB Silane may be used to add a 4FB linker to glass/silica surfaces.

4FB Silane

25 mg

S-5005-025

$295

SHNH Modification Kit for Technetium=99M LabelingTechnetium Conjugation SHNH Kit

SHNH, used for linking technetium-99m, readily reacts with primary amines. Technetium labeling of biomolecules with this reagent has been widely used; Over 200 references can be found by searching PubMed; keyword HyNic. S-HyNic may also be used for technetium labeling.

SHNH Technetium Conjugation Kit

Kit

S-9001-2

$425

SHTH Conjugation SHNH Kit

This SHTH Conjugation Kit is a general kit that can be used to conjugate any amine containing biomolecules to any other amine containing biomolecule. The kit includes the SHTH version of HyNic and S-4FB plus all of the necessary reagents and buffers to activate and conjugate your biomolecules.

SHTH Conjugation Kit

Kit

S-9003-1

$425